Hqhno
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HQNO is an inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein, a component of complex III. 1 In Vibrio alginolyticus, HQNO blocks 90% the activity of the sodium transporting NADH oxidase at a concentration of 40 M. 2 It is a useful tool for probing the mechanisms of electron transfer and proton or sodium translocation by the respiratory chain.
Description. 2-heptyl-4-hydroxyquinoline N-oxide is an inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559. It is a monohydroxyquinoline and a quinoline N-oxide. ChEBI.
Jan 1, 2016 Pseudomonas aeruginosa autolysis is a programmed cell death process induced by the quorum sensing regulated molecule HQNO. After growing for 48 hours, planktonic cultures of P. aeruginosa began to exhibit cell lysis, reflected by a decrease in OD 600nm (Figures 1A and S1A, BC) and also in the number of colony forming units (CFUs) (Figures 2A and S1D).
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Jul 25, 2022 INTRODUCTION. Pseudomonas aeruginosa is a ubiquitous Gram-negative bacteria able to colonize all types of living entities due to its metabolic versatility and adaptability. In humans, it behaves as an opportunistic pathogen, causing a broad spectrum of life-threatening acute and chronic infections in the urinary tract, burn and wound injuries, ventilator-associated pneumonia, and bacteremia ().
Feb 4, 2023 1. Introduction. Toxoplasma gondii (T. gondii) is an intracellular parasite that can widely infect humans and other warm-blooded animals and causes zoonosis.It is estimated that approximately 3050% of the world's population has been infected with T. gondii (Robert-Gangneux and Dard, 2012). ...
Jul 1, 2018 Type II NADH:quinone oxidoreductase (NDH-2) is a proposed drug-target of major pathogenic microorganisms such as Mycobacterium tuberculosis and Plasmodium falciparum.Many NDH-2 inhibitors have been identified, but rational drug development is impeded by the lack of information regarding their mode of action and associated inhibitor-bound NDH-2 structure.
2-Heptyl-4-hydroxyquinoline N-oxide (HQNO), a major secondary metabolite and virulence factor produced by the opportunistic pathogen Pseudomonas aeruginosa, acts as a potent inhibitor of respiratory electron transfer and thereby affects host cells as well as microorganisms. In this study, we demonstrate the previously unknown capability of environmental and pathogenic bacteria to transform and ...
Aug 30, 2022 Pseudomonas aeruginosa infections are increasingly difficult to treat due to the development of antimicrobial resistance. Here, the authors describe the synthesis, characterisation and efficacy of ...
Jan 31, 2024 Background: The cytochrome bc 1 /b 6 f complex, also known as complex III, plays a central role in coupling an electron transport chain with transmembrane (TM) proton translocation, which drives ATP synthesis in photosynthesis and cellular respiration, 2 complementary processes that are essential for sustaining the balance of oxygen and carbon dioxide cycling on Earth.
Type II NADH:quinone oxidoreductase (NDH-2) is a proposed drug-target of major pathogenic microorganisms such as Mycobacterium tuberculosis and Plasmodium falciparum.Many NDH-2 inhibitors have been identified, but rational drug development is impeded by the lack of information regarding their mode of action and associated inhibitor-bound NDH-2 structure.
Aug 31, 2022 Understanding quorum sensing (QS) and its role in the development of pathogenesis may provide new avenues for diagnosing, surveillance, and treatment of infectious diseases. For this purpose, the availability of reliable and efficient analytical diagnostic tools suitable to specifically detect and q
Type II NADH:quinone oxidoreductase (NDH-2) is a proposed drug-target of major pathogenic microorganisms such as Mycobacterium tuberculosis and Plasmodium falciparum. Many NDH-2 inhibitors have been identified, but rational drug development is impeded by the lack of information regarding their mode
Nov 16, 2016 Introduction. Pseudomonas aeruginosa is a multi-antibiotic resistant pathogen commonly responsible for hospital-acquired infections and is the main cause of morbidity and mortality in cystic fibrosis .The pathogenicity of P.aeruginosa is multifactorial and host specific relying on the coordinated production of multiple virulence factors and the formation of antibiotic tolerant biofilms [2,3].
Apr 1, 2023 Plaques of T. gondii-infected Vero cells were formed. Fig. 2 shows that HQNO significantly reduced the invasion and proliferation ability of T. gondii after 48 h, 72 h, and 96 h of incubation (P 0.05). Specifically, compared with the control groups, the PV number decreased significantly (Fig. 2 ab, P 0.05), both pre-and post-infection, and the average number of tachyzoites within ...
Jan 25, 2016 After growing for 48 hr, planktonic cultures of P. aeruginosa began to exhibit cell lysis, reflected by a decrease in OD 600nm (Figures 1 A and S1 AS1C) and also in the number of colony forming units (CFUs) (Figures 2 A and S1 D). This observation is not limited to a specific strain (Figures S1 A and S1B) or a specific growth condition as it is observed both in 96-well plates (Figures 1 A ...
HQNO is a potent inhibitor of mitochondrial type II NADH:quinone oxidoreductase (NDH-2) in many species, including Yarrowia lipolytica, S. cerevisiae, Gluconobacter oxydans, T. gondii, P. falciparum, and S. aureus.HQNO targets the Q-site of NDH-2. HQNO concentrations are varied from 0 to 100 M and 0 to 300 M for wild-type (WT) and I379E C. thermarum NDH-2 variant, respectively to determine ...
Apr 26, 2021 The effects of respiratory inhibitors, quinone analogues and artificial substrates on the membrane-bound electron transport system of the fastidious -proteobacterium Eikenella corrodens grown ...
Jan 21, 2019 Selectively methylated analogues of naturally occurring 2-heptyl-4(1H)-quinolones, which are alkaloids common within the Rutaceae family and moreover are associated with quorum sensing and virulence of the human pathogen Pseudomonas aeruginosa, have been prepared.While the synthesis by direct methylation was successful for 3-unsubstituted 2-heptyl-4(1H)-quinolones, methylated derivatives of ...
Jan 21, 2019 Abstract. Selectively methylated analogues of naturally occurring 2-heptyl-4(1H)-quinolones, which are alkaloids common within the Rutaceae family and moreover are associated with quorum sensing and virulence of the human pathogen Pseudomonas aeruginosa, have been prepared.While the synthesis by direct methylation was successful for 3-unsubstituted 2-heptyl-4(1H)-quinolones, methylated ...
HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III.
The quinol-fumarate reductase (QFR) respiratory complex of Escherichia coli is a four-subunit integral-membrane complex that catalyzes the final step of anaerobic respiration when fumarate is the terminal electron acceptor. The membrane-soluble redox-active molecule menaquinol (MQH2) transfers electrons to QFR by binding directly to the membrane-spanning region. The crystal structure of QFR ...
Oct 5, 2018 Protein complex characterization. To understand the kinetic and structural properties of Pa-NQR, the recombinant protein complex was purified and compared with Vc-NQR, which is the best-characterized member of the family (29, 33, 48, 49).The Pa-NQR operon was cloned into the pBAD HisB plasmid, and the protein complex was expressed (using arabinose as a gene expression inducer) in nqr ...
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